{"id":11381,"date":"2025-07-26T21:55:36","date_gmt":"2025-07-26T19:55:36","guid":{"rendered":"https:\/\/valintermed.com\/?p=11381"},"modified":"2025-07-26T21:55:36","modified_gmt":"2025-07-26T19:55:36","slug":"defitsit-glitseraldegid-3-fosfatdegidrogenazy","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/deficiency-of-glitseraldegid-3-phosphatdehydrogenase\/","title":{"rendered":"Glyceraldehyde-3-phosphate dehydrogenase deficiency"},"content":{"rendered":"
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Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) deficiency is a rare, inherited disorder of metabolism caused by a deficiency of an important enzyme involved in glycolysis. Glyceraldehyde-3-phosphate dehydrogenase plays a key role in carbohydrate metabolism by catalyzing the reaction between glyceraldehyde-3-phosphate and NAD+, which results in the formation of 1,3-bisphosphoglycerate. Deficiency of this enzyme results in the accumulation of intermediates and impaired energy metabolism in cells, which can manifest through a wide range of symptoms, including myopathy, neuropathy, and dysfunction of various organs.<\/p>\n

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