{"id":11291,"date":"2025-07-27T02:25:37","date_gmt":"2025-07-27T00:25:37","guid":{"rendered":"https:\/\/valintermed.com\/?p=11291"},"modified":"2025-07-27T02:25:37","modified_gmt":"2025-07-27T00:25:37","slug":"folievo-defitsitnaya-anemiya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/foliated-deficiency-anemia\/","title":{"rendered":"Folate deficiency anemia"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Folate deficiency anemia is a type of anemia that occurs due to a lack of folate (vitamin B9) in the body. Folate plays a key role in the synthesis of nucleic acids and the production of red blood cells, so its deficiency leads to a decrease in hemoglobin levels and impaired hematopoiesis. This condition is characterized by large, deformed red blood cells, which affects the transfer of oxygen to tissues, causing their hypoxia. Folate deficiency anemia can develop both in isolation and as part of other diseases, such as anemia due to vitamin B12 deficiency or chronic diseases.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/foliated-deficiency-anemia\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/foliated-deficiency-anemia\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/foliated-deficiency-anemia\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/foliated-deficiency-anemia\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/foliated-deficiency-anemia\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/foliated-deficiency-anemia\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/foliated-deficiency-anemia\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/foliated-deficiency-anemia\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/foliated-deficiency-anemia\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/foliated-deficiency-anemia\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The history of folate deficiency anemia research dates back to the mid-20th century, when folate was first isolated from the liver in 1941. This discovery became the basis for further research on the importance of vitamin B9 in the body. In 1965, the relationship between folate deficiency and anemia was described, which contributed to the development of diagnostics and therapy for this disease. Interestingly, in 1998, mandatory standards for fortification of food products with folic acid were introduced in the United States. This innovation reduced the incidence of folate deficiency anemia, especially among pregnant women, which emphasizes the importance of vitamin B9 in preventing various abnormalities in fetal development.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>According to the World Health Organization, folate deficiency anemia affects approximately 500 million people worldwide. This pathology is most common in developing countries, where folate deficiency in the diet is a common problem. In Russia, the prevalence of folate deficiency anemia in the general population is about 1-2%, but among pregnant women this figure reaches 20%. The age groups most susceptible to developing the disease are infants, adolescents and the elderly. Specific populations, such as people with certain diseases (for example, celiac disease or alcoholism), are also at risk.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are a number of genetic factors that predispose to the development of folate deficiency anemia. The most studied mutations are in genes responsible for folate metabolism, such as MTHFR (methylenetetrahydrofolate reductase). These mutations can reduce the activity of enzymes involved in the conversion of folate into active forms, which leads to vitamin deficiency. Polymorphism variants in these genes affect homocysteine and folate levels, which in turn are associated with the risk of anemia. Other genes, such as ABCG2 and SLC46A1, have also been shown to be associated with impaired absorption of vitamin B9.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are numerous risk factors that contribute to the development of folate deficiency anemia:<\/p>\n<ul>\n<li>Lack of folate-rich foods in the diet (green leafy vegetables, legumes, eggs).<\/li>\n<li>Chronic diseases such as celiac disease or Crohn&#039;s disease that affect nutrient absorption.<\/li>\n<li>Alcoholism leading to impaired absorption of folate.<\/li>\n<li>Pregnancy and lactation - increased need for vitamin B9.<\/li>\n<li>Certain medications that can inhibit folate metabolism (antifolates, high doses of aspirin).<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of folate deficiency anemia includes several stages and is based on a combination of clinical manifestations and laboratory methods. The main symptoms of the disease are:<\/p>\n<ul>\n<li>Fatigue and weakness.<\/li>\n<li>Dizziness and shortness of breath during physical exertion.<\/li>\n<li>Paleness of the skin and mucous membranes.<\/li>\n<li>Deformation of the lips and manifestations of stomatitis.<\/li>\n<\/ul>\n<p>Laboratory tests include:<\/p>\n<ul>\n<li>Determination of hemoglobin and hematocrit levels.<\/li>\n<li>Measurement of serum folate levels.<\/li>\n<li>Complete blood count and additional tests to detect macrocytic anemia.<\/li>\n<li>Checking vitamin B12 levels to rule out differential diagnoses.<\/li>\n<\/ul>\n<p>Radiological examinations are usually not required, but in some cases gastroscopy may be necessary to evaluate the gastrointestinal tract. Differential diagnosis should be made with other types of anemia, such as vitamin B12 deficiency anemia or anemia due to chronic diseases.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of folate deficiency anemia is aimed at eliminating folate deficiency and restoring normal hemoglobin levels. The main approaches to therapy include:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>General treatment: Dietary changes, including increasing intake of foods high in folate.<\/li>\n<li>Pharmacological treatment: administration of folic acid in the form of tablets or injections depending on the severity of the deficiency.<\/li>\n<li>Surgical treatment is necessary if anemia is caused by surgical conditions (eg, bowel resection).<\/li>\n<li>Other therapies may include management of underlying medical conditions and B vitamin supplementation.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>Folic acid (in tablet and injection form).<\/li>\n<li>Combined vitamin preparations containing folate.<\/li>\n<li>Medicines to improve absorption (in case of concomitant gastrointestinal diseases).<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of folate deficiency anemia includes regular blood tests for hemoglobin and folate levels, as well as assessment of the patient&#039;s clinical status. The prognosis is generally favorable with prompt treatment, but complications such as cardiovascular disease are possible as a result of anemia caused by prolonged hypoxia.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Folate deficiency anemia may present differently in different age groups. In infants and children, folate deficiency may delay normal development and absorption, while in older adults, the condition is often associated with underlying diseases and decreased gastrointestinal function. In older adults, anemia may be more severe and require a comprehensive approach to treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is the main cause of folate deficiency anemia?<\/strong> The main reason is a lack of folate in the diet or its poor absorption in the body.<\/li>\n<li><strong>What are the symptoms of folate deficiency anemia?<\/strong> Symptoms include fatigue, paleness, dizziness, and shortness of breath on exertion.<\/li>\n<li><strong>How is folate deficiency anemia diagnosed?<\/strong> Diagnosis is based on blood tests and assessment of clinical symptoms.<\/li>\n<li><strong>Can folate deficiency anemia be cured?<\/strong> Yes, with proper therapy and dietary changes, the disease is treatable.<\/li>\n<li><strong>Who is at risk for this disease?<\/strong> At risk are pregnant women, people with chronic diseases and alcoholics.<\/li>\n<\/ul>\n<p>Advice from Dr. Oleg Korzhikov on folate deficiency anemia:<\/p>\n<ul>\n<li><strong>What should I do if I have symptoms of anemia?<\/strong> It is recommended that you immediately consult a doctor and undergo diagnostics.<\/li>\n<li><strong>What diet can help prevent folate deficiency anemia?<\/strong> Include green vegetables, legumes, eggs and citrus fruits in your diet.<\/li>\n<li><strong>Do I need to take any supplements?<\/strong> Yes, if you are diagnosed with folate deficiency, your doctor may prescribe folic acid.<\/li>\n<li><strong>How often should you get your folate levels tested?<\/strong> If you have predispositions or symptoms, checks should be carried out regularly.<\/li>\n<li><strong>Is it possible to cope with anemia without medication?<\/strong> In some cases, it is possible to correct the condition through diet, but this should be agreed with a doctor.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Folate deficiency anemia is a type of anemia that results from a lack of folate (vitamin B9) in the body. Folate plays a key role in<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-11291","post","type-post","status-publish","format-standard","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/11291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=11291"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/11291\/revisions"}],"predecessor-version":[{"id":15924,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/11291\/revisions\/15924"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=11291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=11291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=11291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}