{"id":11209,"date":"2025-07-27T06:27:10","date_gmt":"2025-07-27T04:27:10","guid":{"rendered":"https:\/\/valintermed.com\/?p=11209"},"modified":"2025-07-27T06:27:10","modified_gmt":"2025-07-27T04:27:10","slug":"semeynaya-gipofibrinogenemiya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/family-hypofibrinogenemia\/","title":{"rendered":"Familial hypofibrinogenemia"},"content":{"rendered":"
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Familial hypofibrinogenemia is an inherited coagulopathic condition characterized by significantly reduced levels of fibrinogen in the blood, leading to impaired end-stage hemostasis and, as a result, an increased risk of thrombosis and bleeding. Normally, fibrinogen, a protein synthesized in the liver, plays a key role in thrombus formation by being converted to fibrin during the coagulation cascade. In hypofibrinogenemia, fibrinogen levels are usually less than 0.5 g\/L, which can cause moderate to severe hemorrhage. Symptoms range from mild bleeding (eg, nosebleeds and gum bleeding) to severe cases requiring emergency intervention. Diagnosis and treatment of this condition are multifaceted tasks that require a thorough approach and multidisciplinary collaboration.<\/p>\n

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