{"id":11176,"date":"2025-07-27T07:59:45","date_gmt":"2025-07-27T05:59:45","guid":{"rendered":"https:\/\/valintermed.com\/?p=11176"},"modified":"2025-07-27T07:59:45","modified_gmt":"2025-07-27T05:59:45","slug":"distrofiya-fuksa","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/fuksa-distrophy\/","title":{"rendered":"Fuchs&#039; dystrophy"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Fuchs&#039; dystrophy (or partial corneal dystrophy) is a genetically determined disease characterized by degenerative changes in the cornea of the eye, which can lead to deterioration of visual function. The pathology under study is mainly manifested by changes in the cellular architecture and metabolism of the cornea, as well as frequent deposition of dystrophic complexes in the corneal stroma. The severity of symptoms may vary, but the most common manifestations are blurred vision, photophobia, and eye discomfort. It is important to note that this disease most often progresses with aging, although genetic factors play a critical role in its occurrence. <\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/fuksa-distrophy\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/fuksa-distrophy\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/fuksa-distrophy\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/fuksa-distrophy\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/fuksa-distrophy\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/fuksa-distrophy\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/fuksa-distrophy\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/fuksa-distrophy\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/fuksa-distrophy\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/fuksa-distrophy\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Fuchs&#039; dystrophy is named after the Austrian ophthalmologist Arnold Fuchs, who first described the disease in the early 20th century. In his research, Fuchs focused on the morphological changes occurring in the cornea and their impact on visual function. Interestingly, the disease remained poorly understood for many decades, and only with the development of molecular genetics did more in-depth studies of its causes and mechanisms of pathogenesis become available. Some sources report that Fuchs&#039; dystrophy may be mentioned in ancient works on ophthalmological practice, but over time it has acquired new meaning in the modern medical context.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Epidemiological studies show that Fuchs dystrophy occurs with a frequency of 1-5 cases per 10,000 people in the population. The disease is more common among women and also tends to have a higher incidence in people over 50 years of age. In some populations, genetic predispositions may play a determining role in prevalence. For example, studies have shown that in families with a history of Fuchs dystrophy, the frequency of its occurrence can reach 25-30%. In addition, statistical data indicate that people with an abnormal chromosomal set (for example, in the presence of chromosomal diseases) have a significantly increased risk of developing dystrophy.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Fuchs&#039; dystrophy is in most cases a hereditary disease associated with mutations in genes responsible for the metabolism and structural integrity of the cornea. Studies have found that the most frequently involved genes are KRT12, COL8A2 and ZEB1, which are located in different parts of the chromosomes. Mutations in these genes can lead to disruption of the synthesis of collagen and other important components necessary for maintaining the normal structure of the cornea. There is also a possibility of mosaic heredity, when the disease can occur even in people with no obvious manifestations in the family history, as well as a high chance of developing dystrophy in people with close relatives suffering from this pathology.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>An important aspect of the development of Fuchs&#039; dystrophy is the patient&#039;s environment and lifestyle. The main risk factors include:<\/p>\n<ul>\n<li>Age - the disease is more common in older people, especially those over 60 years of age.<\/li>\n<li>Gender - women are more susceptible to this pathology than men.<\/li>\n<li>Heredity - the presence of cases of dystrophy in the family significantly increases the risk.<\/li>\n<li>Comorbidities such as diabetes and hypertension may contribute to the development of the pathology.<\/li>\n<li>Eye effects - Chronic or excessive exposure to sunlight and ultraviolet radiation can accelerate pathogenic changes in the cornea.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of Fuchs&#039; dystrophy is based on clinical examination and the use of modern imaging methods. The main symptoms of the disease include:<\/p>\n<ul>\n<li>Blurred vision, especially in low light conditions.<\/li>\n<li>Photophobia and discomfort in the eyes.<\/li>\n<li>The appearance of a &quot;curtain&quot; before the eyes.<\/li>\n<li>Increased healing time after corneal injuries or surgeries.<\/li>\n<\/ul>\n<p>Laboratory tests usually include tests for infections and inflammatory processes. Radiological examinations, such as optical coherence tomography and endothelial cell counts, greatly enhance diagnostic capabilities. Differential diagnosis is also an important part to exclude other forms of dystrophy and corneal problems.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment for Fuchs dystrophy may vary depending on the stage of the disease and the individual needs of the patient. In most cases, conservative treatment involves the use of moisturizing drops and corneal stabilizers aimed at reducing symptoms. However, if the disease progresses and significant vision loss develops, surgical methods become more relevant. The most common procedure is keratoplasty, which involves transplanting a donor cornea. In some cases, laser vision correction or restoration using modern bioprostheses may be used. <\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>Artificial tears (various solutions for moisturizing the eyes).<\/li>\n<li>Drops with antioxidants.<\/li>\n<li>Preparations containing corticosteroids.<\/li>\n<li>Special ointments and gels to protect the cornea.<\/li>\n<li>Immunosuppressive drugs (if necessary).<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of Fuchs&#039; dystrophy includes regular visual acuity and corneal health checks. Patients should undergo control examinations at least once a year, which will allow assessing the dynamics of the disease and adjusting the treatment tactics. The prognosis is quite individual and varies from stabilization of the condition to the need for surgical intervention. Complications such as infection or corneal thrombosis may occur in cases where the disease is advanced or cannot be properly controlled.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Fuchs&#039; dystrophy can manifest itself differently depending on the age group. In childhood, the disease is extremely rare and is usually detected only during a detailed examination. In older people, it can manifest itself in a much more pronounced form, which requires an individual approach to diagnosis and treatment. At the same time, elderly patients often have concomitant pathologies, which can reduce the effectiveness of traditional treatment methods.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What are the main symptoms of Fuchs&#039; dystrophy?<\/strong> The main symptoms include blurred vision, photophobia, eye discomfort and noticeable loss of vision in low light conditions.<\/li>\n<li><strong>How does age affect disease progression?<\/strong> In older people, Fuchs&#039; dystrophy often manifests itself with more pronounced symptoms, which is associated with age-related changes in the cornea.<\/li>\n<li><strong>Which treatment method is most effective?<\/strong> Surgical techniques such as keratoplasty are the most effective treatment for progressive Fuchs&#039; dystrophy.<\/li>\n<li><strong>How often should I get checked?<\/strong> It is recommended to undergo follow-up examinations at least once a year to monitor the condition of the cornea.<\/li>\n<li><strong>Can Fuchs&#039; dystrophy be prevented?<\/strong> Complete prevention is not possible, but the risk of developing the disease can be reduced by controlling factors such as UV radiation and dysplasia.<\/li>\n<\/ul>\n<p>Dr. Oleg Korzhikov&#039;s advice on the disease is as follows: &quot;It is extremely important for patients suffering from Fuchs&#039; dystrophy not to ignore the first symptoms and to undergo regular examinations by an ophthalmologist. A healthy lifestyle, a balanced diet, and protecting the eyes from exposure to sunlight can play a significant role in slowing the progression of the disease.&quot;<\/p>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Fuchs&#039; dystrophy (or another name - partial corneal dystrophy) is a genetically determined disease characterized by degenerative changes in the cornea of the eye,<\/p>","protected":false},"author":1,"featured_media":17979,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-11176","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/11176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=11176"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/11176\/revisions"}],"predecessor-version":[{"id":16039,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/11176\/revisions\/16039"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/17979"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=11176"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=11176"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=11176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}